Human Physiology 17

The middle ear plays a vital role in the sense and sensitivity of hearing. Of the various characteristics that distinguish mammals from other vertebrates, several pertain specifically to the middle-……続きを見る

Developmental genetic studies of the spine and linkage and family-based association studies have led to recent advances in understanding the genetic etiology of idiopathic, neuromuscular, and congen……続きを見る

Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the f……続きを見る

Contents Philip C. Sharpe, Rosemary S. Harrison, and David P. Fairlie: Amyloid Peptides and Proteins in Review. - Marilena Kampa, Artemissia-Phoebe Nifli, George Notas, Elias Castanas: Polyphenols a……続きを見る

Mark P. Mattson, Ph.D. is Chief of the Laboratory of Neurosciences at the National Institute on Aging in Baltimore, where he leads a multi-faceted research team that applies cutting-edge technologie……続きを見る

Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of nat……続きを見る

This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug……続きを見る

Since its ?rst description in 1942 in both serum and cerebrospinal ?uid, transthyretin (TTR) has had an eventful history, including changes in name from “prealbumin” to “thyroxine-binding prealbumin……続きを見る

Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an exte……続きを見る

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***Transient Receptor Potential Channels***offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles……続きを見る

Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was enti……続きを見る

In recent years, we have witnessed a rapid expansion of our knowledge regarding the role of the endothelium in the control of vascular tone (and organ perfusion) in health and disease. Physiology, p……続きを見る

The ability to measure accurately the hormones regulating calcium homeosta sis is the fundamental first step toward understanding the roles these hormones play in health and disease. Techniques for ……続きを見る

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or……続きを見る

Contents E.I. Christensen and R. Nielsen: Role of Megalin and Cubilin in Renal Physiology and Pathophysiology G. Zifarelli and M. Pusch: CLC Chloride Channels and Transporters: A Biophysical and Phy……続きを見る

Translational medicine underpins vascular medicine. It is fundamental to understanding how we treat patients with vascular disease and more importantly, how to prevent it. It is the rationale for dr……続きを見る

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in……続きを見る

The monograph introduces innate immunity as second authority in the ovary besides the endocrine system. Innate immunity appears to orchestrate follicular atresia, follicle rupture, follicle transfor……続きを見る

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or……続きを見る

According to the classical theory of functional structure of bone which was developed by J. Wolff (1884, 1892) and W. Roux (1895) following the investigations of the functional architecture of the s……続きを見る

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A new presentation of physiological regulatory mechanisms and therapeutic applications is given in this book. It represents a collection of the most up-to-date information in cholecystokinin (CCK) r……続きを見る

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Traditionally, cardiac hypertrophy is regarded as an adaptation of the heart to permanent mechanical overload. Regardless of the fact that many different and often unknown primary causes can result ……続きを見る

Nitric oxide (NO) is a simple gas with free radical properties. No one would have imagined a role for such a simple substance in the human body. In 1998, R. E Furchgott, E Murad, and L. J. Ignarro r……続きを見る

Glomerular flltration represents one of the basic mechanisms in the function of an organism. Our understanding of this process is still quite fragmentary. Regulation of blood flow and pressure, toge……続きを見る

In January 1980, the First Symposium on the Measurement of Tis sue Oxygen Pressure in Patients was held in Frankfurt. After a 4-year "rest period," the organizers of the 1984 symposium, Profes sor R……続きを見る

Quantitative anaesthesia - exact registration of the degree of anaesthesia - has long been the anaesthetist's dream. Such pre cision could decrease the risk for the patient. Can -this dream now be r……続きを見る

1.1 Overview The precise knowledge of the three-dimensional (3-D) assembly of biological structures is still in its origin. As an example, a widely accepted concept and common belief of the structur……続きを見る